No, not usually. The site at which the needle for tissue removal is introduced is locally anesthetized, so that the actual examination process remains painless.
After the procedure, it may occasionally happen that the puncture site is still a bit sore. Sometimes bruises are formed, which can cause problems for a few more days. In comparison, the so-called vacuum biopsy is somewhat more stressful than the punch biopsy because the procedure takes longer and the puncture site is slightly larger. But overall, the whole thing usually runs smoothly.
Author:Dr. med. Jörg Zorn