The measurement of the hCG concentration in the blood serum, like the hormone detection in urine, is primarily suitable as a pregnancy test.
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Normally, human chorionic gonadotropin (hCG) is only found in blood and urine during pregnancy. Namely, after the hormone production in the placenta cells has begun following the implantation of the embryo in the uterine lining. In serum, the pregnancy hormone can be detected at the earliest 7 days after conception.
When evaluating measurement results (after blood sampling), the following should be noted:
- Proof of pregnancy: Individual examinations of the hCG concentration for diagnostic statements on the course of pregnancy are useless because of very strongly fluctuating norm values.
- Serum hCG detection: often positive one week after conception
- hCG detection in urine: usually two weeks after conception positive
- during the first seven weeks of pregnancy: doubling of the hCG concentration every 2 to 2.5 days
- Multiple pregnancy: from the 10th week of gestation higher hCG levels than with singleton pregnancy
- Early miscarriage: too low, but above all too slowly rising or falling values in the first trimester of pregnancy
- after birth: hCG normal after 11-17 days
When is the hCG value highest?
Human gonadotropin (hCG) is used to hormonally maintain pregnancy. During the first two weeks after fertilization, the hCG measured in the blood serum increases rapidly, doubling at least every two days, later every three days and after five weeks, only every five days. In the first trimester of pregnancy, between the 9th and 10th week of pregnancy, the hCG reaches its highest level. After that, it drops again, remains relatively constant at a lower level until birth, and returns to about one to two weeks after birth Initial level as before pregnancy.
Does the hCG value say anything about the duration of pregnancy?
The duration of an existing pregnancy can only be deduced to a very limited extent. Due to the very fluctuating norm values, single examinations are useless for diagnostic statements and only multiple measurements, which represent a concentration course, are helpful.
The following correlations are given in the literature:
Standard values (hCG concentration in serum in units per liter)
3rd week of pregnancy: 5-50 U / l
4th week of pregnancy: 50-500 U / l
5th week of pregnancy: 100-5,000 U / l
6th week of pregnancy: 500-10,000 U / l
7th week of pregnancy: 1,000-50,000 U / l
8th week of pregnancy: 10,000-100,000 U / l
9th + 10th week of pregnancy: 15,000-200,000 U / l
11th-14th Pregnancy week: 10,000-100,000 U / l
2nd trimester of pregnancy. 8,000-100,000 U / l
Third trimester of pregnancy: 5,000-65,000 U / l
How does the hCG increase after an IVF?
After in vitro fertilization (IVF), the steady increase in female pregnancy hormone (hCG) is similar to natural pregnancy. However, the hCG concentration reaches a plateau earlier, namely already 24 days after the infiltration, in order to decrease again later.
Author: Dr. Hubertus Glaser