High-density lipoprotein (HDL) cholesterol, which is part of the total cholesterol in the blood, has protective properties because this cholesterol is transported back from the vessels to the liver where it is broken down, so that it does no harm to the vessels.
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On the contrary, it has its own anti-inflammatory activity and improves vascular function. It thus prevents multiple calcification of the arteries (atherosclerosis).
Therefore, high levels of HDL cholesterol are desired. On the other hand, the total cholesterol and LDL (low density lipoprotein) cholesterol should be low because they have a vascular damaging effect.