Coumarin derivatives or coumarin derivatives are derived from phytochemicals, the coumarins. Synthetic drugs used today are phenprocoumon, Warfarin and acenocoumarol. These are highly effective anticoagulants that can be taken in tablet form.
The active ingredients inhibit the vitamin K-dependent formation of coagulation factors in the liver. However, the anticoagulation takes some time, so that usually take a few days until the desired full effect occurs.
Coumarin derivatives are suitable for temporary coagulation inhibition, but also for long-term therapy. They are also used in the replacement of heart valves, atrial fibrillation and generally with an increased tendency to form blood clots.
When coumarin derivatives are taken, regular control of blood coagulation is important to check for the resulting increased bleeding tendency. The optimal therapeutic range must be determined individually for the various diseases. For this, weekly blood samples are usually necessary. Blood clotting data and tablet intake are also recorded in a passport that you always have to carry with you for safety (for example, in the event of an accident or injury).
Cumarin derivatives should not be used in patients with an increased tendency to bleed, with gastrointestinal ulcers, with untreated or poorly adjusted high blood pressure, as well as during pregnancy and lactation.