A blood CRP increase is a rather unfavorable sign in Crohn's disease. At least for the moment. Because it indicates that the disease activity is just increasing or particularly high.
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Background: The C-reactive protein, often referred to by doctors as CRP, is an inflammatory parameter. Not only in Crohn's disease, but also in many other diseases, the determination of the CRP value is mainly used for follow-up diagnostics. If the protein in the blood rises, this is always an indication that the inflammatory processes in the body are currently particularly active. Physicians speak of CRP and similar proteins of acute phase proteins.
Declining CRP value indicates disease calming
The C-reactive protein is produced in the liver and then released into the blood. The production increases in an acute infection or an inflammatory reaction in the body, in the blood plasma, however, an elevated CRP value is always detectable only 12 to 24 hours later.
Back to Crohn's disease: A CRP increase is a sign of a high or increasing activity of the disease now existing. It says nothing about the prognosis or the further course. When Crohn's disease settles again, the CRP level also decreases and is then a diagnostic criterion for a disease arrest.
Author:Dr. med. Jörg Zorn