What is intraepithelial neoplasia?

Intraepithelial neoplasia, often abbreviated to IEN, is a malignant lesion of the mucosa. For example, in the uterus, the prostate or just in the intestine. Intraepithelial neoplasia is considered an early form of cancer.

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What does this mean in connection with Crohn's disease? If an examination of tissue samples under the microscope indicates that an IEN or an early form of colorectal cancer exists, the affected section of the intestine should be removed.

In general, Crohn's disease seems to slightly increase the risk of colorectal cancer. This is especially true when the colon is affected. However, it is important to realize that this is a relatively increased risk. Meaning, it is slightly higher than usual, but in absolute terms still very low.

Authors: Dr. med. Anne-Kristin Schulze &Dr. med. Jörg Zorn

Do you have your own experiences or a different opinion? Then write a comment (please observe rules).
Comments (10)
Histology Duodenal mucosa from the papillary region
10 Friday, 08 December 2017 at 20:51
Sabine S.
Low grade intraepithelial neoplasia of the duodenal mucosa. Well compatible with a tubular adenoma with low-grade intraepithelial neoplasias: According to clinical data derived from the papilla.
No infiltrative growth.
About the distance in the healthy decides the endoscopic picture?
Recommended check-up in 6 months. Definitive surgical care is not desired at this time.
Can someone tell me what that means? And what could an operative removal look like? I was quite frightened when describing such a thing.
Coecum polyp: tubular adenoma with high grade IEN control in 6 months
9 Sunday, July 30, 2017 at 16:31
Anne K.
What is the recidivism rate?
Low grade neoplasia
8 Thursday, December 22, 2016 at 08:07
Navigator editors
Hello Sabine,
An adenoma is a benign node. In this adenoma, however, some cells have formed, which are suspected of cancer (so no cancer, but the cells could eventually become).
Therefore, the doctor advises to remove the adenoma. By curative excision is meant that a complete elimination of the problem is achieved. It is impossible to say in advance whether such a cell island will become a true cancer, but with the removal of the adenoma you are on the safe side.
Best regards
Dr. J. anger
Pathological findings
7 Thursday, 22nd December 2016 at 07:38
Meaning: tubular adenoma with intraepithelial low-grade neoplasia (low dysplasia), focal with increased proliferation - curative excision recommended
6 Monday, March 21st, 2016 at 10:25 am
hans seitz
which means: high grade prostatic intraepithelial neoplasia / HG-PIN) + mild gland-deltoid fibromuscular hyperplasia
please do not despair
5 Thursday, November 05, 2015 at 19:16
Navigator Team
Hello Renate,

Of course, this can not be seriously assessed from a distance, which is why the following can not replace the judgment of your local doctors. But the finding does not sound as bad to us as it probably does to you.
Neoplasia is a precancer, not a cancer. No acute danger, just something to keep an eye on. The fact that your doctor considers it necessary to have a check-up only in six months shows that he, too, judges it that way.
And the other findings (gastritis & Co.) are all easy to treat and no reason for oversized worries.
Maybe a change in your diet makes sense if your mucous membranes are so affected in the stomach.

All the best and kind regards
Your navigator team
Low grade intraepithelial neoplasia, Oligo crypt adenoma of the duodenal mucosa
4 Thursday, November 05, 2015 at 18:47
Renate T.
I'm shocked because I'm not just the o.a.Diagnosis was obtained, but a small adenoma bud with mucus depletion was also found (was removed) as well as partial goblet cell reduction, single mitotic figures, slightly enlarged nuclei.

I am literally at the end and do not really know what to think of these findings, especially as I can not find a translation for most of the findings.

There is also a recurrent subacute antral gastritis, a regenerative hyperplasia, the Dixon score indicates type C gastritis, reflux oesophagitis 0-1, a flat ulcerous lesion.

Unfortunately, my GP only called me late for the result. In this phone call, he mentioned that a control gastroscopy in 6 months is advisable because it would be a precancer. A phone call I find this result, which also makes me very unsure, not exactly appropriate.
intraepithelial neoplasia in the stomach
3 Sunday, April 12, 2015 at 2:32 pm
I can not find therapy on the internet, except that chemo and radiation do not work. What is being done? What awaits me? Mucous membrane that is affected. Except controls, I can not find anything. The fear is deep. Please, somebody tell me roughly and generally what you can do.
No panic
2 Friday, April 10, 2015 at 20:28
editorial team
Hello Heike,

yes, that is curable. And you certainly do not have to die. Although it is always a bit frivolous to make concrete forecasts from a distance, but in your case it seems to be an early form that is still easy to remove.

Your navigator team
intraepithelial neoplasia in the stomach
1 Friday, April 10, 2015 at 5:56 pm
I am completely finished. I got this diagnosis yesterday. I'm afraid. It is the first stage. In 4 weeks another reflection with contrast agent is made. Is that curable? How is the therapy? Is there any? I do not wanna die. Please give me answers