Questions about tumor pain therapy Here you will find questions and answers about the different aspects of treating pain in a tumor. In the menu on the left, you can select the topic. Which medications fall under Tier 1 of WHO Tier 2 therapy? How do bisphosphonates work against the pain of bone metastases? What are the main painkillers in cancers that do not contain opioids (morphine, etc.)? How does radionuclide therapy relieve pain in bone metastases? Why are pain relievers with an anti-inflammatory component used in tumor-related bone pain? Which medicines fall under Tier II of WHO step therapy? How do you develop bone pain in cancers? Which medications fall under Tier III of WHO step therapy? Why is a continuous long-term treatment recommended in tumor pain therapy? Can low-potency opioids be combined with potent opioids? Why should low level II (WHO) opioids not be combined with potent level III opioids? Why is it so important for WHO Stage II pain medications not to exceed the maximum daily dose? Do WHO Standard III painkillers have a maximum daily dose?